Systemic Photoprotection in Melanoma and Non-Melanoma Skin Cancer

Non-melanoma skin cancers (NMSCs), which include basal cell carcinoma (BCC), squamous (SCC), and actinic keratosis (AK), are the most common cancer diseases in Caucasian race. If diagnosed late improperly treated, BCC SCC can become locally advanced metastasize. Malignant melanoma (MM) is less frequent but more lethal than NMSC. Given individual social burdens of cancers, performing an adequate prevention needed. Ultraviolet (UV) ray exposure one main risk factors for cancer. Thus, first-choice strategy represented by photoprotection that be both topical systemic. The latter consists oral administration molecules protect human against damaging effects UV rays, acting through antioxidant, anti-inflammatory, or immunomodulator mechanisms. Although several compounds commonly used photoprotection, only a few have demonstrated their effectiveness clinical trials been included international guidelines NMSC (i.e., nicotinamide retinoids). Moreover, none them as able to prevent MM. Clinical preclinical data regarding systemic reported this review, with focus on mechanisms involved photoprotective properties.